A self micro-emulsifying oral pharmaceutical composition of a hydrophilic drugor itspharmaceutical acceptable salt and the preparation method thereof aredisclosed. Thecomposition comprises hydrophilic drug such as bendamustine or gemcitabine,solvent,surfactant and hydrophilic carrier, and has good bioavailability andstability. Said hydrophiliccarrier is compatible with drug solution and surfactant.
