PROTÉINE L1 TRONQUÉE DU PAPILLOMAVIRUS HUMAIN DE TYPE 52

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专利权人:

XIAMEN INNOVAX BIOTECH CO., LTD.;XIAMEN UNIVERSITY

发明人:

LI, SHAOWEI,MO, XIAOBING,WEI, MINXI,PAN, HUIRONG,ZHANG, JUN,XIA, NINGSHAO

申请号：

EP11800199

公开号：

EP2589604A4

申请日:

2011.07.01

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.

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