WOOLFORD ALISON JO-ANNE,HOWARD STEVEN,BUCK ILDIKO MARIA,CHESSARI GIANNI,JOHNSON CHRISTOPHER NORBERT,TAMANINI EMILIANO,DAY JAMES EDWARD HARVEY,CHIARPARIN ELISABETTA,HEIGHTMAN THOMAS DANIEL,FREDERICKSON
申请号：
NZ61557212
公开号：
NZ615572A
申请日:
2012.04.20
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Provided are bicycle-heterocycle compounds, of the general formula (I), where the variables are as defined in the specification. Preferably the variable Q is N. Examples of the compounds include 1-(6-Bromo-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1- yl)-ethanone, 3,3-Dimethyl-1-[(2S)-2-[(3R)-3-methylpiperazin-1-yl]butanoyl]-2,3-dihydro-1H-indole-6-carbonitrile, hydrochloride salt and 1-{ 6-Benzyl-3,3-dimethyl-1H,2H,3Hpyrrolo[3,2-c]pyridin-1-yl} -2-[(2R,5R)-5-methyl-2-[(piperidin-1-yl)carbonyl]piperazin-1-yl]ethan-1-one dihydrochloride. The compounds may antagonise inhibitors of apoptosis proteins (IAPs). The compounds may be useful in the treatment of cancer.
