Blankenship, John W.,Sewell, Elaine Todd,Tan, Philip
申请号:
AU2012245260
公开号:
AU2012245260B2
申请日:
2012.04.20
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH). In one embodiment, the multi-specific polypeptide therapeutics bind both PSMA-expressing cells and the T-cell receptor complex on T cells to induce target-dependent T-cell cytotoxicity, activation and proliferation.