The present invention relates to the use of sophoricoside in the manufacture of a medicament for the prevention and/or the treatment of articular cartilage degeneration or osteoarthritis in the post-menopausal women. It is effective and has no side-effects on uterus, breasts and the like as animal-derived estrogen does. It is easy to be extracted and the source thereof is abundant. Therefore, it has a promising marketing prospect.
