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Polymorphic mixture of Rifaximin and its use for the preparation of solid formulations
专利权人:
EUTICALS SPA
发明人:
Paride Grisenti,Maria Argese,Daniele Pengo,Maria Donata Grilli,Emanuela Fumagalli,Giuseppe Motta
申请号:
US16567852
公开号:
US10745415B2
申请日:
2019.09.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A Rifaximin polymorphic mixture of α/β form in a relative ratio of 85/15±3 and a process for its preparation. The polymorphic mixture of Rifaximin is for use as a medicament, in particular in the treatment of traveler's diarrhea and hepatic encephalopathy. A pharmaceutical composition comprises the polymorphic mixture of Rifaximin as active ingredient, in particular, a solid formulation, more in particular, a film coated tablet. A polymorphic form of crude wet rifaximin and of purified wet rifaximin their use are used as intermediates in a process for the preparation of Rifaximin polymorphic mixture of α/β form in a relative ratio of 85/15±3.
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