NadA, App and ORF40 function as adhesins in N.meningitidis. Adhesion can bemodulated by targeting these three proteins. NadA allelic variants aredisclosed. Autoproteolytic cleavage of App is disclosed, as is removal of theactivity by mutagenesis. App is processed and secreted into culture mediumwhen expressed in E.coli. Mature App proteins are disclosed. Knockout mutantsare disclosed. Vesicles from non-Neisserial hosts with heterologous adhesinexpression are disclosed.
