FELICETTI, PATRIZIA,FINCHAM, CHRISTOPHER INGO,GIOLITTI, ALESSANDRO,MAGGI, CARLO ALBERTO,QUARTARA, LAURA,ROSSI, CRISTINA
申请号：
CA2583920
公开号：
CA2583920C
申请日:
2005.09.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Non-peptide compounds having activity as selective antagonists ofbradykinin (BK) B2 receptor. The compounds are a pharmaceuticallyacceptable salt of general formula (I)(see formula I)in which- R is hydrogen or methyl；- W is a single bond or an oxygen atom；- n=3；- X is hydrogen or a-NR1R2 amino group in which R1 and R2 areindependently hydrogen or a group selected from methyl, ethyl, n-propyl, or isopropyl；- Y is a -NR3R4R5 quaternary ammonium group in which R3, R4, R5are independently a group selected from methyl, ethyl, n-propyl,isopropyl, n-butyl, isobutyl, or n-pentyl；enantiomers thereof； or enantiomeric mixtures thereof.
