The present invention synthetically solves a medical compound scattering problem of a conventional technology which requires a lot of manpower and consumes a lot of chemical solutions since a medical compound scattering work is cumbersome and is periodically performed. As an antifungal non-woven fabric sheet for disease prevention and pest control in which a continuous medical compound is impregnated having a maximized effective pest control period and efficiency of sterilization or killing insects, etc. as a layered structure. In the layered structure, a medical compound coating layer is bonded using upper and lower water soluble adhesive layers between non-woven fabric sheets. The non-woven fabric sheets are formed of an outer skin based on a permeable non-woven fabric with gas-permeable properties on one side to be touched with the outside and an inner skin based on a waterproof film coating layer on the other side. The medical compound coating layer is obtained by mixing and impregnating a medical compound for disease prevention and pest control such as disinfectant or the like and absorbent resins. The adhesive layers comprise long and width directional binding wires in a grid structure. The antifungal non-woven fabric sheet for the disease prevention and pest control in which the continuous medical compound is impregnated can be easily mounted on a pen or the like by using length and width directional binding wires in a grid structure. Accordingly, the antifungal non-woven fabric sheet can perform disease prevention and pest control with indirect scattering of the medical compound in an enclosed space or an opened space without a separate disinfection device and the direct scattering of the medical compound when being widely used such as a cover sheet for disease prevention, a disinfection mat, a tree trunk protective guard, and the like, wherein the cover sheet for disease prevention prevents a bacteria such as a virus or the like from being entered from the