This disclosure relates, inter alia, to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.Linvention concerne, entre autres, des composés qui inhibent lactivité de lhistone déméthylase. En particulier, linvention concerne des composés qui inhibent lhistone lysine déméthylase KDM5B, des compositions pharmaceutiques et des méthodes dutilisation, telles que des méthodes de traitement du cancer à laide des composés et compositions pharmaceutiques de linvention.
