PROBLEM TO BE SOLVED: To provide a GPR40 activator having, as an active ingredient, a compound having a new GPR40 agonist effect, a salt thereof, a solvate of either or the like, above all, an insulin secretagogue, a prophylactic and/or therapeutic agent for diabetes, obesity and the like.SOLUTION: The compound is represented by formula (I) (wherein n is 0-2 p is 0-4 j is 0-3 k is 0-2 ring A is an aryl group or a heterocyclic group optionally substituted by L ring B is a benzene ring, a pyridine ring or a pyrimidine ring X is O, S or -NR7- and R1 to R7 and L are each a specific group) and includes a salt or solvate thereof.COPYRIGHT: (C)2012,JPO&INPIT【課題】新規なGPR40アゴニスト作用を有する化合物またはその塩またはそれらの溶媒和物等を有効成分とするGPR40活性化剤、とりわけインスリン分泌促進剤、糖尿病、肥満等の予防及び/または治療剤の提供。【解決手段】式(I)【化1】(式中、nは0~2;pは0~4;jは0~3;kは0~2;環AはLで置換されていてもよいアリール基、ヘテロ環基;環Bはベンゼン環、ピリジン環、ピリミジン環;XはO、S、-NR7-;R1~R7、Lは特定の基を示す)で表される化合物、またはその塩またはそれらの溶媒和物。【選択図】なし
