Disclosed embodiments of an endotracheal tube (ETT) guard system help to hinder self-extubation of the ETT of an awake patient who may reflexively attempt removal, but also allow early mobilization and exercise necessary for preservation of muscle strength. Embodiments may include an ETT holder, which may be generic ETT holders offered by various medical device companies, or a specially configured ETT holder as described herein. Embodiments also may include a sensor that alarms when the ETT guard is moved beyond pre- set motion thresholds.