The present invention relates to a pharmaceutical composition for inhibiting proliferation and metastasis of colorectal cancer and metrocarcinoma, which comprises at least one kind of STIM1 inhibitor. The present invention also relates to another pharmaceutical composition for inhibiting proliferation and metastasis of colorectal cancer and metrocarcinoma, which comprises at least one kind of store-operated calcium channel inhibitor.本發明係關於一種用於抑制結腸直腸癌細胞及子宮上皮癌細胞增生及轉移之醫藥組合物,其係包含至少一種基質作用分子1抑制劑。本發明另關於一種用於抑制結腸直腸癌細胞及子宮上皮癌細胞生長及轉移之醫藥組合物,其係包含至少一種鈣池調控鈣離子通道活性抑制劑。