DAVID J. KING,HELEN TONI JUN,MARILYN KEHRY,PETER BOWERS
申请号：
BR112017016638
公开号：
BR112017016638A2
申请日:
2016.02.03
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the Lymphocyte Activation Gene-3 (LAG-3). The invention provides a LAG-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the LAG-3-binding agent to treat a disorder or disease that is responsive to LAG-3 inhibition, such as cancer or an infectious disease.
