PROTEINE IL-15 HETERODIMERIQUE ET SES UTILISATIONS

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专利权人:

LTD.;SHANGHAI HENGRUI PHARMACEUTICAL CO.;SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.

发明人:

QU, XIANGDONG,YE, XIN,YUAN, JIJUN,ZHANG, LEI,CHEN, KAN,ZHANG, LIANSHAN,CAO, GUOQING,XU, ZHIBIN,TAO, WEIKANG

申请号：

CA2935599

公开号：

CA2935599A1

申请日:

2014.12.25

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Disclosed are an IL-15 heterogeneous dimer protein and uses thereof. The IL-15 heterogeneous dimer protein comprises protein (I) and protein (II). The protein (I) is formed by means of reconstruction between IL-15 or a modification thereof and a first Fc modification； the protein (II) a second Fc modification, or is formed by means of reconstruction between IL-15Ra or a modification thereof and the second Fc modification； and the first Fc modification and the second Fc modification are connected in a manner of Knob-into-Hole. The IL-15 heterogeneous dimer protein has obvious tumor suppression activity, and has better bioactivity and an extended in-vivo half-life period compared with a single IL-15 molecule.

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中国工程科技知识中心

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