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CANCER CELL SPECIFIC IMAGING PROBES AND METHODS OF USE
专利权人:
发明人:
Nobuhide Ueki,Michael J. Hayman
申请号:
US14911187
公开号:
US20160184459A1
申请日:
2014.08.07
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a compound having the structure:wherein X is an imaging agent containing at least one amine nitrogen Y is a chemical linker, wherein Y is present or absent, and when present Y is a chemical linker containing at least one amine nitrogen or Y is a para-aminobenzyl alcohol linker Z is CH3 or CF3 R1 is —H, —NR2R3, —NH—C(═O)—R4, —NH—C(═O)—OR4, —CH2—C(═O)—NR5R6, —OR7, —CO2R7, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, or heteroaryl, wherein R2, R3, R4, R5, R6 and R7 are each, independently, —H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, an amino acid or an oligopeptide wherein an amine of the amino acid or oligopeptide is substituted or unsubstituted and n is an integer from 0 to 6or a diastereomer, enantiomer or pharmaceutically acceptable salt of the compound.
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