Pharmaceutical compositions containing, as active ingredient, granulocyte-colony stimulating factor mutant protein or transferrin fusion protein thereof
Jeong-Hyeok Yoon,Byung-Ha Chang,Bong-Seok Jin,Ji Young Bae,Soon Nam Kim,Kyeong Su Park,Yeong kyu Park,Hanjo Kim,Youngju Seo,Wooseong Jeong,KyungTae Kang
申请号：
US15327838
公开号：
US10479822B2
申请日:
2014.11.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a fusion protein in which transferrin is peptide-bonded to a terminal of a granulocyte-colony stimulating factor (G-CSF) protein or a G-CSF mutant protein in which the 116th threonine is substituted with cysteine in the amino acid sequence of the G-CSF. Specifically, the granulocyte-colony stimulating factor (G-CSF) mutant protein of the present invention or the transferrin fusion protein thereof displays a significantly increased specific activity and blood stability, compared with the conventional human G-CSF, and has a higher purification efficiency than the conventional PEGylated G-CSF characterized by the extended half-life, so that it can be advantageously used for preventing or treating ischemic diseases or neutropenia.
