JOHNS HOPKINS UNIVERSITY;CARDIOXYL PHARMACEUTICALS, INC.
发明人:
COURTNEY, STEPHEN MARTIN,KALISH, VINCENT JACOB,BROOKFIELD, FREDERICK ARTHUR,COHEN, ANDREW D
申请号：
NZ59577007
公开号：
NZ595770A
申请日:
2007.03.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
ABSTRACT - 595770 Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is H； R2 is H, benzyl, or tetrahydropyran-2-yl； R3, R5 and R7 are H； and R4 and R6 are independently selected from H, Cl, F, I, Br, SO2CH3, phenyl, CN, OCH3, OCF3, t- Bu, O-iPr, 4-nitrophenyloxy, propane-2-thiyl, propane-2-sulfinyl, morpholino, N-methyl-piperazino, dimethylamino, piperidino, cyclohexyloxy, cyclopentylsulfanyl, phenylsulfanyl, and phenylsulfinyl, provided that at least one of R4 and R6 is H. These compounds are suitable for treating, preventing, delaying the onset of, or delaying the development of a disease or condition that is responsive to nitroxyl therapy in an individual in need thereof, wherein the disease or condition is a cardiovascular disease or condition such as heart failure.
