Their works and methods of use. 1. Characteristic requirement 1: a formula compound (1) or a pharmaceutically acceptable salt of the compound, wherein: r739es-l-cycloa or l-r696；A ring a was selected from the preparation group (2)；each m is independently 0, 1, 2, 3 or 4； L is a covalent bond, or a divalent, straight or branched, saturated or unsaturated, Catura straight or branched hydrocarbon chain； each R¹ is independently hydrogen, straight or branched C₁₋₆ alkyl wherein the C₁₋₆ alkyl is optionally substituted with 1-4 R³ groups,Cyclododecyl composed of 3-6 members, or saturated heterocyclododecyl composed of 3-6 members, composed of 1-2 heteroatoms, independent of oxygen, nitrogen or sulfur, or: R 1 and R 2 in carbon adjacent to R1 constitute an aperiodic ring composed of 3-7 optional members, composed of 0-2 heteroatoms. 1. In addition to the nitrogen atom of polyr1, oxygen, nitrogen or sulfur should be selected independently；o: R1 and R 2 group in a carbon not close to R1, together with their atoms, form an aperiodic ring composed of 4-7 alternative members. The ring has 0-2 non atoms, separated from oxygen, nitrogen or sulfur. In addition, there are nitrogen atoms, including R1；L is a divalent, straight or branched, saturated or unsaturated, Civa straight or branched hydrocarbon chain； Rʸ is -N (R) ₂,wherein each R is independently selected from hydrogen or C₁₋₆ aliphatic optionally substituted with 1-2 groups independently selected from halogen, -O or -N (R) ₂,o: In the same nitrogen atom, two R groups and nitrogen atoms form a saturated or partially unsaturated acyclic ring, which is composed of 3-8 members. In addition to nitrogen, nitrogen, oxygen or sulfur, the ring is optionally replaced by a non atom. 1-2 independently selected halogen group, - o-n (R) 832222；Each R2 is an independent hydrogen, deuterium and tar c83318323；-Oxo o: two groups of carbon are added to form a saturated and replaceable ring carbide composed of 3-7 members, or a non positive
