An intermediate layer having a drug substance-containing nucleus containing butyl scopolamine bromide and water-insoluble particles in the center, and sequentially containing, from the drug substance-containing nucleus side, water-insoluble particles and covering the drug substance-containing nucleus, talc and at least 1 A fine granule having a bitter taste masking layer containing a seed water-insoluble polymer, an orally disintegrating tablet comprising an externally formed component with respect to the fine granule, and a method for producing the same.ブチルスコポラミン臭化物及び水不溶性粒子を含む原薬含有核を中心に有し、原薬含有核側から順に、水不溶性粒子を含み、かつ、原薬含有核を被覆する中間層と、タルク及び少なくとも１種の水不溶性ポリマーを含む苦味マスキング層と、を有する細粒、並びに、細粒に対して外側の賦形成分を含む口腔内崩壊錠、及びその製造方法。
