Package comprising a syringe and a blister package are described. The blister package incorporates elements that allow one-handed opening. This result is achieved by a flange region seal width which is substantially reduced adjacent the flange region with reference to the packed syringe compared to the distal region seal width. This enables the syringe to be squeezed out of the package with one hand so that upon removal of the syringe from the blister package, the flange region and the proximal region exit the package prior to the distal region. Also described are methods of removing a syringe from a package using only one hand.