A system and method for temperature drift correction capability in a CT detector module is disclosed. A scintillator array of a CT detector module has a plurality of scintillator cells configured to detect high frequency electromagnetic energy passing through an object, with a plurality of photodiodes in a photodiode array optically coupled to the scintillator array to detect light output therefrom. A computer is provided that is programmed to measure a response of the plurality of photodiodes as a function of temperature, determine a transfer function indicative of the response of the plurality of photodiodes as a function of temperature, normalize the transfer function to a virtual operating temperature, measure a temperature of the photodiode array prior to a scan, determine a correction factor from the normalized transfer function based on the measured photodiode temperature and the virtual operating temperature, and apply the correction factor to the photodiode outputs.