LUEOEND, Rainer Martin,MACHAUER, Rainer,RUEEGER, Heinrich,VEENSTRA, Siem Jacob
申请号：
ES12772462
公开号：
ES2565229T3
申请日:
2012.08.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), or a pharmaceutically acceptable salt thereof, ** Formula ** wherein R1, R2, R3, R4, R5 and R6 are thus defined to provide a compound selected from: [6 - ((R ) -2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H- [1,3] oxazin-4-yl) -5-fluoro-pyridin-2-yl] -amide acid 5-Cyano-3- methyl-pyridine-2-carboxylic acid, having the formula ** Formula ** [6 - ((R) -2-amino-5,5-difluoro-4-methyl-5,6-dihydro 3-Chloro-5-cyano-pyridine-2-carboxylic acid -4H- [1,3] oxazin-4-yl) -5-fluoro-pyridin-2-yl] -amide, having the formula ** Formula ** [6 - ((R) -2-amino-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H- [1,3] oxazin-4-yl) -5- 3-Chloro-5-cyano-pyridine-2-carboxylic acid fluoro-pyridin-2-yl] -amide, having the formula ** Formula ** [6 - ((R) -2-amino-5.5 3-Chloro-5-trifluoromethyl-pyridine -difluoro-4-methyl-5,6-dihydro-4H- [1,3] oxazin-4-yl) -5-fluoro-pyridin-2-yl] -amide -2-carboxylic, which has the formula ** Formula ** and [6 - ((R) -2-amino-5,5-difluoro-4-methyl-5,6-dihyd 4-Chloro-1- difluoromethyl-1H-pyrazol-3-carboxylic acid ro-4H- [1,3] oxazin-4-yl) -5-fluoro-pyridin-2-yl] -amide, having the formula **Formula**Un compuesto de fórmula (I), o una sal farmacéuticamente aceptable del mismo,**Fórmula** en donde R1, R2, R3, R4, R5 y R6 se definen así para proporcionar un compuesto seleccionado de: [6-((R)-2-amino-5,5-difluoro-4-metil-5,6-dihidro-4H-[1,3] oxazin-4-il)-5-fluoro-piridin-2-il]-amida del ácido 5-ciano-3- metil-piridina-2-carboxílico, que tiene la fórmula**Fórmula** [6-((R)-2-amino-5,5-difluoro-4-metil-5,6-dihidro-4H-[1,3] oxazin-4-il)-5-fluoro-piridin-2-il]-amida del ácido 3-cloro-5- ciano-piridina-2-carboxílico, que tiene la fórmula**Fórmula** [6-((R)-2-amino-5,5-difluoro-4,6,6-trimetil-5,6-dihidro-4H-[1,3] oxazin-4-il)-5-fluoro-piridin-2-il]-amida del ácido 3-cloro- 5-ciano-piridina-2-carboxílico, que tiene la fórmula**Fórmula** [6-((R)-2-amino-5,5-difluoro-4-metil-5,6-dihidro-4H-[1,3]oxazin-4-il)-5-fluoro-piridin-2-il]-amida del ácido 3-cloro-5
