Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices

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专利权人:

Deyun Wang

发明人:

Deyun Wang,Paramjit Arora

申请号：

US12811088

公开号：

US08871899B2

申请日:

2008.12.31

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention relates to a peptide having one or more stable, internally-constrained HBS α-helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a portion of a class I N-peptide helix of a viral (e.g., HIV-I) coiled-coil assembly. Methods of inhibiting viral infectivity of a subject by administering these peptides are also disclosed.

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