Accordingly the present invention provides a pharmaceutical oil in water nano emulsion with a pharmaceutically active substance. The selected pharmaceutically active substance is encased in monounsaturated fatty acid droplets with the droplets having an average particle size in the range of 60 to 200 nm. The nano emulsion is also provided with a non ionic surfactant system which is a mixture of polyethers macrogolglycerides and polysaccharides along with pharmaceutically acceptable adjuvants. The present invention also provides a process for the preparation of pharmaceutical oil in water nano emulsion.
