An adjusting method and an adjusting system are provided. The adjusting method for human body support device includes the following steps: extracting a pressure distribution information when a user is lying on a human body support device; analyzing a posture of the user based on the pressure distribution information; analyzing a human musculoskeletal distribution information of the skeleton-muscle of the user and a plurality of coordinate values corresponding to the skeleton-muscle of the user based on the pressure distribution information; obtaining a plurality of high-risk regions corresponding to the plurality of pressure regions based on the human musculoskeletal distribution information, a plurality of coordinate values corresponding to the skeleton-muscle of the user, and the posture of the user; and adjusting a pressure value configuration of an airbag module of the human body support device based on the plurality of high-risk regions.