Provided Here in are phosphor(n)amidatacetal and phosph(on)atacetal compounds, their preparation and their uses, such as treating liver diseases or nonliver diseases via intervening in the molecular pathway in the liver.本案提供胺基磷酸酯(膦醯胺酯)縮醛以及磷酸酯(膦酸酯)縮醛化合物、該等化合物的製備及該等化合物的用途,例如經由介入肝臟中的分子路徑來治療肝病或非肝臟疾病。