PHARMACEUTICAL FORMULATIONS OF TROPOMYOSIN RELATED KINASE (TRK) INHIBITORS

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专利权人:

发明人:

LIEBERMAN HARVEY,YANG DONGLAI,PHILBROOK C MICHAEL,SANTOS MICHAEL,HO CHRIS

申请号：

IN201737025475

公开号：

IN201737025475A

申请日:

2017.07.18

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

Pharmaceutical formulations with a tropomyosin related kinase inhibitor (Trk inhibitor) are disclosed. The pharmaceutical formulations comprise 3 (3 methoxy 4 ((4 methoxybenzyl)oxy)benzyl) 6 (1 methyl 1H pyrazol 4 yl) 3H imidazo[4 5 b]pyridin 2 amine in microcrystalline suspension formulations in its monohydrate form which shows improved characteristics over the anhydrate form and in extended release formulations. The extended release pharmaceutical formulations comprise 3 (3 methoxy 4 ((4 methoxybenzyl)oxy)benzyl) 6 (1 methyl 1H pyrazol 4 yl) 3H imidazo[4 5 b]pyridin 2 amine loaded microspheres.

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