The present invention relates to a variant and fusion of fibroblast growth factor 19 (FGF19), a variant and fusion of fibroblast growth factor 21 (FGF21), fibroblasts having one or more activities such as glucose lowering activity Fusion factor of growth factor 19 (FGF19) and / or fibroblast growth factor 21 (FGF21), and protein sequence and peptide sequence of fibroblast growth factor 19 (FGF19) and / or fibroblast growth factor 21 (FGF21) (And peptidomimetics) variants or fusions, and methods of treatment and use in the treatment of hyperglycemia and other disorders. [Selection] Figure 3A本発明は、グルコース降下活性などの1種以上の活性を有する、線維芽細胞増殖因子19(FGF19)の変種及び融合体、線維芽細胞増殖因子21(FGF21)の変種及び融合体、線維芽細胞増殖因子19(FGF19)及び／又は線維芽細胞増殖因子21(FGF21)の融合体、並びに線維芽細胞増殖因子19(FGF19)及び／又は線維芽細胞増殖因子21(FGF21)のタンパク質配列及びペプチド配列(及びペプチド模倣体)の変種又は融合体、並びに高血糖症及び他の障害の治療方法及び治療における使用に関する。【選択図】図３Ａ
