COE, JOTHAM WADSWORTH,DEHNHARDT, CHRISTOPH MARTIN,JONES, PETER,KORTUM, STEVEN WADE,SABNIS, YOGESH ANIL,WAKENHUT, FLORIAN MICHEL,WHITLOCK, GAVIN ALISTAIR
申请号：
PE0001282014
公开号：
PE10592014A1
申请日:
2012.07.11
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Indazoles derivatives relates to compounds of formula (i) wherein R1 is Halo R2 is alkyl (C1 - C6) optionally substituted with Fluorine X is a Link -, co -, - or - CH2 - SO2 - R3 is aril1, het1, among others, where aril1 is phenyl or naphthyl het1 is a Aromatic heterocycle of 5 or 6 members n is 1 or 2.Preferred compounds are: {2 - [6 - (2 - ethyl - 4 - 5 - fluoro - hydroxy phenyl) - 1H - indazol - 3 - yl] - 1,4,6,7 - tetrahydro imidazo [4,5-c] pyridin-3 (IL - 5 - fluoro - 4} - {2 - phenyl) methanone - [6 - (2 - ethyl - 4 - 5 - fluoro - hydroxy phenyl) - 1H - indazol - 3 - yl] - 1,4,6,7 - tetrahydro imidazo [4,5-c] pyridin - il - 5} - isotiazol - 3 - il - methanone among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Janus Kinase (JAK) being useful in the treatment of Asthma, allergic rhinitis, chronic bronchitisSE REFIERE A COMPUESTOS DERIVADOS DE INDAZOLES DE FORMULA (I) DONDE R1 ES HALO R2 ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON FLUOR X ES UN ENLACE, -CO-, -SO2- O -CH2- R3 ES ARIL1, HET1, ENTRE OTROS, DONDE ARIL1 ES FENILO O NAFTILO HET1 ES UN HETEROCICLO AROMATICO DE 5 O 6 MIEMBROS n ES 1 O 2. SON COMPUESTOS PREFERIDOS: {2-[6-(2-ETIL-5-FLUORO-4-HIDROXI-FENIL)-1H-INDAZOL-3-IL]-1,4,6,7-TETRAHIDRO-IMIDAZO[4,5-c]PIRIDIN-5-IL}-(4-FLUORO-FENIL)-METANONA {2-[6-(2-ETIL-5-FLUORO-4-HIDROXI-FENIL)-1H-INDAZOL-3-IL]-1,4,6,7-TETRAHIDRO-IMIDAZO[4,5-c]PIRIDIN-5-IL}-ISOTIAZOL-3-IL-METANONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE JANUS QUINASA (JAK) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, RINITIS ALERGICA, BRONQUITIS CRONICA
