FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (CNIC)
发明人:
RODRÍGUEZ RAMIRO Almudena,BARTOLOMÉ IZQUIERDO Nahikari,GARCÍA DE YÉBENES Virginia
申请号：
US201615573394
公开号：
US2018117076(A1)
申请日:
2016.05.13
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Provided herein are compositions comprising miR-28, including compositions comprising miRNA-28 expression vectors, as well as compositions comprising compounds that mimic the miRNA activity of miR-28. In certain embodiments, the compositions comprise oligomeric compounds comprising oligonucleotides having nucleobase sequence identity to miR-28. In certain embodiments, the nucleobase sequence of an oligonucleotide having identity to a miR-28 comprises a seed region of the miRNA-28. The compositions may comprise one or more lipids. In certain embodiments, the one or more lipids are selected from a cationic lipid, a neutral lipid, a sterol, and a disaggregation lipid. Also provided herein are methods for the treatment of mature B-cell neoplasms, comprising administering to a subject having a mature B-cell neoplasm a composition comprising miR-28, including compositions comprising miRNA-28 expression vectors, and/or a composition comprising a compound that mimics the miRNA activity of miRNA-28.
