DUFFY KEVIN J.,ERICKSON-MILLER CONNIE L.,EPPLEY DANIEL F.,JENKINS JULIAN,LUENGO JUAN I.,LIU NANNAN,PRICE ALAN T.,SHAW ANTONY N.,VISONNEAU SOPHIE,WIGGALL KENNETH
申请号：
CZ20023852
公开号：
CZ303176B6
申请日:
2001.05.24
申请国别(地区):
CZ
年份:
2012
代理人:
摘要：
Je popsána sloucenina, kterou je 3'-{N'-[1-(3,4-dimethylfenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-yliden]hydrazino}-2'-hydroxybifenyl-3-karboxylová kyselina, farmaceuticky prijatelná sul, hydrát ci solvát této slouceniny, a také farmaceutický prostredek s obsahem této slouceniny a její použití jako antitrombocytopénické cinidlo mající aktivitu proti trombocytopénii zpusobené ruznými faktory, napr. transplantací orgánu, myelodysplastickými syndromy, aplastickou anémií, leukémií, virovou, mykotickou, mikrobiální ci parazitární infekcí, atd.In the present invention, there is disclosed 3'-{N'-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid, pharmaceutically acceptable salt, hydrate or solvate thereof as well as a pharmaceutical composition in which the compound is comprised as well as the use of the compound for treating thrombocytopenia, in a mammal, including a human, the thrombocytopenia being caused by various factors, such as organ transplant, myelodysplastic syndromes (MDS), aplastic anemia, leukemia, viral, fungal, microbial or parasitic infection, etc.
