The present invention relates to a sutureless method of repairing soft tissue defects in soft tissue including ligaments such as anterior cruciate ligaments (ACLs). In particular, the present invention relates a sutureless method of repairing soft tissue defect comprising: (i) providing a collagen-containing patch adapted to enclose at least a portion of said soft tissue defect； (ii) contacting said soft tissue defect and/or collagen-containing patch with a sensitizer； (Hi) enclosing said soft tissue defect in said collagen-containing patch to produce a bioactive chamber； and (iv) adhering said collagen-containing patch to said soft tissue defect without sutures.
