Rizwan Sharnez,William Trieu,Marc A. Caporini,Ron C. Kelly,Neill Burt,Laura Nicholson,Twinkle R. Christian
申请号：
US16494165
公开号：
US20200157141A1
申请日:
2018.03.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.
