A novel [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof； a pharmaceutical composition containing the [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof； and a use of the [alpha]-substituted glycineamide derivative or a pharmacologically acceptable salt thereof for medical purposes. The present invention provides a compound which has an inhibitory activity on TRPM8 and is represented by general formula (I) [wherein A1 represents a C6-10 aryl group or the like； A2 represents a C6-10 aryl group or the like； X represents CH or the like； Y represents -CR1R2- or the like； R1 and R2 independently represent a hydrogen atom or the like； R3 and R4 independently represent a halogen atom or the like； and n represents 1 or 2] or a pharmacologically acceptable salt thereof. The compound (I) according to the present invention can be used as a therapeutic or prophylactic agent for diseases or conditions associated with afferent nerve hyperexcitability or injury.本發明提供一種新穎之α-取代甘胺醯胺衍生物、或其藥理學上所容許之鹽、含有其之醫藥組成物及其醫藥用途。本發明提供具有TRPM8抑制作用的一般式(I)[式中，A1為C6-10芳基等，A2為C6-10芳基等，X為CH等，Y為-CR1R2等，R1及R2獨立為氫原子等，R3及R4獨立為鹵原子等，n為1或2]所示化合物、或其藥理學上所容許之鹽。進而，本發明之化合物(I)可利用作為起因於傳入神經之過剩興奮或障礙的疾病或症狀的治療或預防藥。
