HUNTINGTON, James Andrew,POLDERDIJK, Stephanie,BAGLIN, Trevor
申请号:
HUE14827185
公开号:
HUE042763T2
申请日:
2014.12.15
申请国别(地区):
HU
年份:
2019
代理人:
摘要:
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.