JANSSEN BIOTECH INC.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人:
申请号:
IL26844519
公开号:
IL268445D0
申请日:
2019.08.01
申请国别(地区):
IL
年份:
2019
代理人:
摘要:
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.