Systems and Methods for Developing Covalent Inhibitor Libraries for Screening Using Virtual Docking and Experimental Approaches

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专利权人:

Northwestern University

发明人:

Alexander V. Statsyuk

申请号：

US16470021

公开号：

US20190362816A1

申请日:

2017.12.15

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Disclosed are methods and systems for screening covalent ligand libraries to identify potential covalent inhibitors. The methods and systems may also be used to generate a covalent inhibitor library from natural ligands. These covalent inhibitors bind to the receptor irreversibly after initial reversible binding. The covalent inhibitor identified or designed using the present methods may specifically bind to and covalently modify a receptor.

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中国工程科技知识中心

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http://www.ckcest.cn/home/