compound, pharmaceutical composition, methods for inhibiting blood thrombus formation or treating blood thrombus formation, preventing blood thrombus formation, treating venous thromboembolism and pulmonary embolism, treating deep vein thrombosis and treating thromboembolic attack , and, use of a compound
ALAN HRUZA,AMJAD ALI,ERIC MERTZ,LINDA L. BROCKUNIER,REMOND MONINGKA,SANTHOSH F. NEELAMKAVIL,SCOTT D. EDMONDSON,SUNG-SAU SO,WANYING SUN,WEIGUO LIU,YING-DUO GAO
申请号：
BR112017015431
公开号：
BR112017015431A2
申请日:
2016.01.15
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention provides a compound of formula II and pharmaceutical compositions, comprising one or more of said compounds, and methods for using said compounds to treat or prevent thrombosis, embolisms, hypercoagulability or fibrotic disorders. The compounds are selective factor xia inhibitors or dual factor xia and plasma kallikrein inhibitors.a presente invenção provê um composto de fórmula i i e composições farmacêuticas, compreendendo um ou mais dos ditos compostos, e métodos para usar os ditos compostos para tratar ou prevenir a trombose, embolias, hipercoagulabilidade ou alterações fibróticas. os compostos são inibidores seletivos do fator xia ou inibidores duplos do fator xia e da calicreína plasmática.
