The invention described herein comprises compounds and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The comounds inhibit signaling by a member of the TGF-β superfamily such as Nodal or Activin本文所述之本發明包含化合物及治療癌症之方法,該方法包含結合另一治療性癌症治療向患有癌症之個體投與該等化合物中之一者。該等化合物抑制TGF-β超家族中成員(例如諾達爾(Nodal)或活化素(Activin))之信號傳導。