PROBLEM TO BE SOLVED: To provide a foamable skin external preparation in which the percutaneous absorption of a water-soluble active ingredient is improved.SOLUTION: A foamable skin external preparation comprises a water-soluble active ingredient in a skin external preparation that generates carbon dioxide, and composed of one or more agents. The foamable skin external preparation at least comprises acidic substance, carbon dioxide generating substance which reacts with the acidic substance to generate carbon dioxide, and a water-soluble active ingredient.COPYRIGHT: (C)2015,JPO&INPIT【課題】水溶性有効成分の経皮吸収性を向上した発泡性皮膚外用剤を提供すること。【解決手段】二酸化炭素を発生する皮膚外用剤中に水溶性有効成分を含有し、一剤又は二剤以上の剤から構成される発泡性皮膚外用剤であって、少なくとも、酸性物質、前記酸性物質と反応して炭酸ガスを発生する炭酸ガス発生物質、水溶性有効成分を含有する発泡性皮膚外用剤。【選択図】図1
