Andreas Zeiher,Stefanie Dimmeler,Christopher Heeschen,Hartmut Ruetten
申请号：
US10979399
公开号：
US08309608B2
申请日:
2004.11.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.
