The United quinolinilo compounds derived from phenyl； Pharmaceutical Composition and its Preparation Process； a method for treating or improving a Syndrome or Disorder, inflammatory disease mediated by ROR gamma T, such as rheumatoid arthritis, psoriasis, Crohn's disease, among others.
LEONARD, KRISTI A.,BARBAY, KENT,EDWARDS, JAMES P.,KREUTTER, KEVIN D.,KUMMER, DAVID A.,MAHAROOF, UMAR,NISHIMURA, RACHEL,URBANSKI, MAUD,VENKATESAN, HARIHARAN,WANG, AIHUA,WOLIN, RONALD L.,WOODS, CRAIG R.
申请号：
CL2015000946
公开号：
CL2015000946A1
申请日:
2015.04.15
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&gamma；t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.“COMPUESTOS DERIVADOS DE QUINOLINA, MODULADORES DEL RECEPTOR NUCLEAR ROR-GAMMA-T； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； PROCESO DE ELABORACIÓN DE LA COMPOSICIÓN； Y SU USO DEL COMPUESTO O COMBINACIÓN DE ESTE EN ARTRITIS REUMATOIDE, PSORIASIS, ENFERMEDAD DE CROHN, ENTRE OTRAS”. PCT
