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Substituted pyridinones as MGAT2 inhibitors
专利权人:
Bristol-Myers Squibb Company
发明人:
DEVASTHALE, Pratik,MOORE, Fang,MIGNONE, James,WANG, Wei
申请号:
ES15795011
公开号:
ES2666569T3
申请日:
2015.06.10
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph or a solvate thereof, wherein: ring A is independently phenyl, tetrahydronaphthalenyl or a heteroaryl of 5 to 10 members comprising carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S; wherein said phenyl, tetrahydronaphthalenyl and heteroaryl are substituted with 0-1 R6 and 0-3 R7; R1 is independently selected from: - (CH2) m- (C3-6 carbocycle substituted with 0-2 Rb and 0-2 Rg), - (CH2) m- (5-6 membered heteroaryl comprising carbon atoms and 1 -4 heteroatoms selected from N, NRe, O and S, wherein said heteroaryl is substituted with 0-1 Rb and 0-2 Rg) and a C1-12 hydrocarbon chain substituted with 0-3 Ra; wherein said hydrocarbon chain can be linear or branched, saturated or unsaturated; R2 is independently selected from: H, halogen, C3-4 cycloalkyl, phenyl substituted with 0-2 Rh and C1-12 hydrocarbon chain substituted with 0-3 Ra; wherein said hydrocarbon chain can be linear or branched, saturated or unsaturated; R3 is independently selected from: - (CH2) n-X- (CH2) mR4, -CONHSO2R1, -NHCOX1SO2Ri, a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S; wherein said heterocycle is substituted with 0-2 Rd; X is independently selected from: CONH and NHCO; X1 is independently C1-4 hydrocarbon chain optionally substituted with C1-4 alkyl or C3-4 cycloalkyl; R4 is independently selected from: C3-6 cycloalkyl substituted with 0-2 Rd, C3-6 cycloalkenyl substituted with 0-2 Rd, - (CH2) m- (phenyl substituted with 0-3 Rd) and a heterocycle from 5 to 6 members comprising carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S; wherein said heterocycle is substituted with 0-2 Rd; R6 is independently selected from: halogen, C1-6 alkyl substituted with 0-2 Rh, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, - (CH2) m-C3-6 cycloalkyl, - (CH2) m -NRfRi, CN, ORi, SRi and 4- to 6-membered heterocycl
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