Method of preparation of biocompatible polymer nanocapsules for drug encapsulation

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专利权人:

发明人:

申请号：

EP12185211.5

公开号：

EP2572708B1

申请日:

2012.09.20

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to a method for preparing a capsule nanoparticle used in encapsulating hydrophobic medicines, comprising the following steps: (A) providing a biocompatible polymer and an organic solution containing a hydrophobic medicine (B) stirring the organic solution at 3-10°C, and titrating with an alcohol solution, so as to make the biocompatible polymer encapsulate hydrophobic medicine to form a capsule nanoparticle (C) ultrasonic vibrating the capsule nanoparticle at 3-10°C (D) filtering the capsule nanoparticle to an average size controllable in the range of 60-450 nm and (E) lyophilizing the encapsulated particles.

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