An antimicrobial, antiseptic, and antibacterial barrier has a flexible shield configured to slidingly engage a urinary catheter. The shield has one or more sections configured to conform and adhere to the urinary meatus and/or surrounding skin or tissues of a target patient. A flexible expandable drape is engaged with the shield and is axially aligned with the catheter to provide an additional layer of protection to prevent the passage of bacteria, fungi, and contaminants into the urinary tract. The shield and drape each comprise an antimicrobial, antiseptic, and antibacterial material.
