An apparatus and method for electromagnetic treatment of living tissues andcells comprising: configuring at least one waveform according to amathematical model having at least one waveform parameter, said at least onewaveform to be coupled to a angiogenesis and neovascularization target pathwaystructure (101); choosing a value of said at least one waveform parameter sothat said at least waveform is configured to be detectable in saidangiogenesis and neovascularization target pathway structure (102); generatingan electromagnetic signal from said configured at least one waveform; andcoupling said electromagnetic signal to said angiogenesis andneovascularization target pathway structure using a coupling device (103).