Disclosed is a medical instrument coating being coated on the surface of a nickel titanium alloy component of a medical instrument. The medical instrument coating comprises an elementary copper phase an amorphous titanium containing substance and a transition layer comprising a copper nickel intermetallic phase. Also mentioned is a preparation method for the medical instrument coating. A medical instrument comprising a copper titanium coating has good blood compatibility and simultaneously can inhibit the endothelialization of the medical instrument surface improving the recovery rate of the medical instrument and prolonging the recovery time window the copper titanium coating belongs to the group of metal composite coatings has a certain toughness and ductility and avoids the large amplitude deformation process of the medical instrument damaging the coating and the mechanical property and the coating quality of the medical instrument comprising a fine nickel titanium alloy component are guaranteed by means of the a method for preparing the coating.
