A medical artificial nerve graft containing silk fibroin used in bridging ofnerve damage and its preparation method. The medical artificial nerve graftis comprised of vessel or comprised of vessel and fibre scaffold, wherein at leastone of the vessel and the fibre scaffold contains component of silk fibroin, andthe wall of the vessel has three-dimensional structure provided with numerousmicroaptures. The preparation method includes the following steps: silk isused to prepare silk fibroin fibre the silk fibroin fibre is used to prepare thevessel or the fibre scaffold containing silk fibroin and combining the fibrescaffold with the vessel i.e. inlaying the fibre scaffold into the vessel andso on.
