Zoltan Kovacs,Garry E. Kiefer,Corinne Bensimon,A. Dean Sherry,Gyula Tircso,Cara Ferreira
申请号：
US13476794
公开号：
US20120276001A1
申请日:
2012.05.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A bifunctional polyazamacrocyclic chelating agent of the formula (I):wherein:and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu a conjugate of the complex covalently attached to a biological carrier and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
